ea0086oc1.6 | Bone and Calcium | SFEBES2022
Kooblall Kreepa
, Hannan Fadil
, Stevenson Mark
, Lines Kate
, Meng Xin
, Stewart Michelle
, Wells Sara
, Gasser Jurg
, Thakker Rajesh
Heterozygous germline gain-of-function mutations of the extracellular calcium-sensing receptor (CaSR), a G-protein coupled receptor (GPCR), result in autosomal dominant hypocalcaemia type 1 (ADH1), which may cause symptomatic hypocalcaemia with low circulating parathyroid hormone (PTH) concentrations and hypercalciuria. Negative allosteric CaSR modulators, known as calcilytics, rectify the gain-of-function caused by CaSR mutations and are a potential targeted therapy for ADH1....